Shop - 5-Amino-1MQ (5mg Vial)

Description

5-Amino-1MQ is a membrane-permeable, small, selective NNMT inhibitor that makes a great component for potential anti-obesity therapies. The Methylquinolinium (MQ) derivative known as 5-Amino-1MQ has demonstrated excellent efficacy in NNMT inhibition, cell viability, and membrane permeability.

Due to increased intracellular NAD+ and SAM, this NNMT inhibitor may be utilized to prevent adipogenesis, and type II diabetes, and reverse diet-induced obesity.

What is 5 Amino 1MQ?

Small chemical 5-Amino-1MQ has the potential to inhibit the activity of the nicotinamide N-methyltransferase enzyme (NNMT). NNMT is mostly active in adipose tissue and is a crucial part of metabolism and energy. By inhibiting NNMT, the cofactor nicotinamide adenine dinucleotide (NAD+) which is essential for cellular metabolism, increases.

This may inhibit NNMT, the cofactor nicotinamide adenine dinucleotide (NAD+), which is essential for cellular metabolism. Because of its function in lowering the risk of diabetes, obesity, metabolic syndrome, atherosclerosis, and other types of cardiovascular disease, renal disease, liver disease, neurodegeneration, and cancer, SIRT1 is frequently referred to as the “longevity gene.”

According to studies, mice administered 5-Amino-1MQ had a 7% lower body mass than controls without changing their food intake. [R]

According to research, lowering NNMT may aid in shrinking fat cells and reducing the size of fat deposits. [R]

How Does 5 Amino 1MQ Work?

As mentioned above, 5-Amino-1MQ works by inhibiting the action of an enzyme called nicotinamide N-methyltransferase (NNMT). NNMT is mostly active in adipose fat tissue and has a substantial impact on energy and metabolism. By inhibiting NNMT, the cofactor nicotinamide adenine dinucleotide (NAD+), which is essential for cellular metabolism, increases.

Because of its function in lowering the risk of diabetes, obesity, metabolic syndrome, atherosclerosis, and other types of cardiovascular disease, renal disease, liver disease, neurodegeneration, and cancer, SIRT1 is frequently referred to as “the longevity gene.”

5 Amino 1MQ Research

Multiple studies have been carried out on 5-Amino-1MQ. However, the available clinical data isn’t sufficient to claim its safety and efficacy for human consumption. Gear City VIP sells 5-Amino-1MQ for research purposes only.

5 Amino 1MQ and Weight Loss

A recent study examined the effects of NNMT inhibitors, such as 5-Amino-1MQ, on high-fat diet-induced obesity in mice. DIO mice treated with the NNMT inhibitor showed a weight loss of 2.0 ± 0.6 g (~5.1% weight loss from baseline measures). Food intake remained the same between the groups suggesting the weight loss effect is primarily related to altered metabolism.

These study findings established NNMT as a potential target for the treatment of obesity and associated metabolic disorders and promote the development of small molecule NNMT inhibitors as therapies to reverse diet-induced obesity. [R]

5 Amino 1MQ May Treat Metabolic Conditions

The enzyme that methylates nicotinamide (NAM), one of the forms of vitamin B3, is known as nicotinamide (NAM) N-methyltransferase (NNMT).

The function of NNMT has recently been shown to go beyond the removal of surplus vitamin B3. Through the consumption of methyl donors and the production of active metabolites, NNMT has been linked to the control of numerous metabolic pathways in tissues like adipose and liver as well as cancer cells. [R]

These studies have given way to future research on the potential of 5 Amino 1MQ as a treatment aid in numerous metabolic conditions.

5 Amino 1MQ and Longevity

As mentioned above, 5-Amino-1mq has the potential to alter NAD levels. This may be very prevalent as studies show NAD to decrease by as much as 50% between the ages of 40 and 60. [R]

Multiple studies have shown that restoring NAD may lead to potentially reversing signs of aging. [R]

5 Amino 1MQ and Muscle Mass

5-Amino-1MQ could potentially be used to increase muscle mass. Lowering NNMT expression has been proven to assist the treatment of muscular illnesses such as muscle atrophy while also promoting the regeneration of aging muscle cells. It can also potentially enhance neuromuscular performance, whether it is during resistance training or muscle damage recovery.

Finally, by inhibiting NNMT, you may potentially restore muscle injury. [R]

5 Amino 1MQ and Muscle Stem Cell Production

In one study, 24-month-old mice were given either control (saline) and low or high doses of NNMTi (NNMT inhibitor) for one week after injury, or control and high dose NNMTi for three weeks after injury. To examine muSC activity, mice were systemically administered 5-ethynyl-2′-deoxyuridine, and all of the mice sustained a localized acute muscular injury to the tibialis anterior (TA) muscle.

Myofiber cross-sectional area (CSA) and contractile activity of the injured TA muscle were measured in vivo in order to gauge the extent of muscle recovery.

Results showed that NNMTi-treated mice had increased muscle stem cell proliferation and subsequent fusion.

This data confirmed changes in fiber size distribution to increased proportions of larger myofibers and fewer smaller fibers in NNMTi-treated mice compared to controls, as well as an approximately 2-fold increase in CSA. [R]